3-(difluoroMethoxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 59619821, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and 3-difluoromethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (Stage 183.1.1) to give the title compound as a white foam. (HPLC: tR 2.48 min (Method A); M+H=437 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 9.01 (s, 1H), 8.61-8.59 (m, 1H), 8.52-8.50 (m, 1H), 8.17-8.13 (m, 2H), 8.02-7.98 (m, 1H), 7.74-7.71 (m, 1H), 7.61-7.59 (m, 1H), 7.39 (t, 1H), 3.90 (s, 3H), 3.59 (s, 3H), 1.95 (s, 3H))

Provenance & Evidence