HCID 59619738, compound → HCID 59619932, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and [3-isopropoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-methanol (Stage 190.1.1) to give the title compound as a white solid. (HPLC: tR 2.19 min (Method A); M+H=459 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.99 (s, 1H), 8.27-8.23 (m, 1H), 8.15-8.10 (m, 2H), 8.03-7.98 (m, 1H), 7.62-7.59 (m, 1H), 7.40-7.37 (m, 1H), 4.84 (br, 1H), 4.76 (hp, 1H), 4.55 (s, 2H), 3.88 (s, 3H), 3.58 (s, 3H), 1.97 (s, 3H), 1.36-1.31 (m, 6H))

Provenance & Evidence