8-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one → HCID 59620097, compound

HRID 445766Notes

Reaction equation

HRID 445766 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]4[C:16]([CH3:21])=[N:17][N:18]([CH3:20])[CH:19]=4)[C:5]=3[C:4]=2[CH:3]=1.[CH3:24][O:25][C:26](=[O:45])[C:27]([CH3:44])([C:29]1[CH:30]=[N:31][CH:32]=[C:33](B2OC(C)(C)C(C)(C)O2)[CH:34]=1)[CH3:28]>>[CH3:24][O:25][C:26](=[O:45])[C:27]([C:29]1[CH:30]=[N:31][CH:32]=[C:33]([C:2]2[CH:11]=[CH:10][C:9]3[N:8]=[CH:7][C:6]4[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]5[C:16]([CH3:21])=[N:17][N:18]([CH3:20])[CH:19]=5)[C:5]=4[C:4]=3[CH:3]=2)[CH:34]=1)([CH3:44])[CH3:28]

Participants

3

Reactant 2

HCID 596197398-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one2×HCID 59619846HCID 59619846, compound

Product 1

HCID 59620097HCID 59620097, compound

Procedure

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 0.215 mmol) and 2-methyl-2-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-propionic acid methyl ester (Stage 229.1.1, 0.279 mmol) to give the title compound as a brown solid. (HPLC: tR 2.28 min (Method A); M+H=471 MS-ES)

Workup

  1. customThe title compound was synthesized in a similar manner

Sources & evidence

ORD record
ord-61168b1637374a2f9be36dc779d70141
Source dataset
uspto-grants-2013_07
Patent number
US08476294B2

Reaction notes

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