反应详情

A mixture of (5-bromo-pyridin-3-yl)-acetic acid (ABCR, Karlsruhe, Germany, 4.54 mmol) and concentrated sulfuric acid (0.02 ml) in MeOH was refluxed for 13.5 h. The RM was concentrated, taken in EtOAc and sonicated. The organic layer was washed with saturated aqueous NaHCO3, with brine, dried over Na2SO4, filtered and evaporated to dryness to give the title compound as a brown oil. (HPLC: tR 2.21 min (Method A); M+H=230, 232 MS-ES)

1. temperaturewas refluxed for 13.5 h
2. concentrationThe RM was concentrated
3. customsonicated
4. washThe organic layer was washed with saturated aqueous NaHCO3, with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customevaporated to dryness