N-Ethyl-4-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinamine → HCID 59619776, compound

Participants

Reaction Steps

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A) and ethyl-[4-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-amine (Stage 235.1.1) to give the title compound as a white solid. (HPLC: tR 2.24 min (Method A); M+H=445 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.91 (s, 1H), 8.16-8.06 (m, 3H), 8.01-7.97 (m, 1H), 7.74-7.69 (m, 1H), 7.61-7.58 (m, 1H), 3.88 (s, 3H), 3.84 (s, br, 3H), 3.56 (s, 3H), 3.36-3.28 (m, 2H), 1.93 (s, 3H), 1.13 (t, 3H))

Provenance & Evidence