HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → [4-(8-Bromo-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-methyl-pyrazol-1-yl]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | [4-(8-Bromo-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-methyl-pyrazol-1-yl]-acetic acid methyl ester | HCID 59620049 | — |
| Product | [4-(8-Bromo-3-methyl-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-methyl-pyrazol-1-yl]-acetic acid methyl ester | HCID 59619953 | — |
Reaction Steps
The title compound was synthesized in a similar manner as described for Stage 245.1.1 using [4-(8-bromo-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-3-methyl-pyrazol-1-yl]-acetic acid methyl ester (Stage 101.1.3, 3.43 mmol) and iodomethane to give the title compound as brown solid. (HPLC: tR 2.42 min (Method A); M+H=430, 432 MS-ES)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476294B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-9dcbc62b03784af782c62fbd6f9c3c4f |
| Source note | uspto-grants-2013_07 |