ethyl (2E)-3-(3,5-difluoro-4-hydroxyphenyl)prop-2-enoate → Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

Participants

Reaction Steps

To a solution of (E)-ethyl 3-(3,5-difluoro-4-hydroxyphenyl)acrylate (10) (0.751 g, 3.29 mmol) in ethanol (20 mL) was added Pd/C (81 mg, 10% Degussa type). A balloon of hydrogen gas was added and the reaction was evacuated and back-filled with hydrogen three times. The reaction was stirred under a hydrogen balloon overnight at room temperature, filtered through a pad of celite and concentrated in vacuo to give ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate (11).

Provenance & Evidence