Ethyl 2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetate → Ethyl 3-(4-hydroxy-2,6-dimethylphenyl)propanoate

HRID 445823Notes

Reaction equation

HRID 445823 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])CC[CH2:5]2.O[C:19]1C=CC(CCC(OCC)=O)=C(C)C=1C>>[OH:1][C:2]1[CH:11]=[C:10]([CH3:19])[C:9]([CH2:8][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:4]([CH3:5])[CH:3]=1

Participants

3

Reactant 2

HCID 57835772Ethyl 2-(6-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetateHCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate

Product 1

HCID 59732650Ethyl 3-(4-hydroxy-2,6-dimethylphenyl)propanoate

Procedure

Similar reaction routes used for the synthesis of (514) was used to synthesize the intermediate ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate (570) (1.2 g, 89.3%) as a white solid.

Workup

  1. customSimilar reaction routes

Sources & evidence

ORD record
ord-6148aea90a8441a4897225f489c89a80
Source dataset
uspto-grants-2013_07
Patent number
US08476308B2

Reaction notes

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