(E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate → Ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)propanoate

Participants

Reaction Steps

To a solution (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652) (420 mg, 1.57 mmol) in ethanol (6 mL) was added Pd/C (42 mg, 10% Degussa type). A balloon of hydrogen gas was added and the reaction was evacuated and back-filled with hydrogen three times. The reaction was stirred overnight at room temperature, was filtered through a pad of celite and concentrated in vacuo to give ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)propanoate (653).

Provenance & Evidence