HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid | HCID 14838401 | — |
| Product | Methyl 5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate | HCID 58566735 | — |
Reaction Steps
Thionyl chloride (0.6 mL, 8.12 mmol) was added slowly to a solution of 5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylic acid (667) (1.1 g, 4.06 mmol) in methanol (41 mL). After refluxing for 3 hours the solvent was removed in vacuo to obtain methyl 5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate (668).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476308B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-52717e0c3b154e5eb285fa06fc5d675d |
| Source note | uspto-grants-2013_07 |