HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (5-Bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methanol | HCID 58566787 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran | HCID 58566467 | — |
Reaction Steps
To a solution of (5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methanol (669) (390 mg, 1.51 mmol) in dichloromethane (15 mL) was added thionyl chloride (0.56 mL, 7.58 mmol). The reaction was stirred at room temperature for 2 hours and then concentrated to afford 5-bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran (670).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476308B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-467e62797f3d4018addc481f7913fce1 |
| Source note | uspto-grants-2013_07 |