HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → (E)-ethyl 3-(4-(benzyloxy)-2-isopropoxyphenyl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Reactant | 4-(Benzyloxy)-2-isopropoxybenzaldehyde | HCID 10635744 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-ethyl 3-(4-(benzyloxy)-2-isopropoxyphenyl)acrylate | HCID 58566403 | — |
Reaction Steps
A solution of 4-(benzyloxy)-2-isopropoxybenzaldehyde (698) (480 mg, 1.776 mmol) and (carbethoxymethylene)triphenylphosphorane (1.1 eq.) in toluene was heated at 100° C. overnight. The reaction was cooled to room temperature and concentrated in vacuo. The crude material was purified by silica gel chromatography (0-50% EtOAc in hexanes) to afford (E)-ethyl 3-(4-(benzyloxy)-2-isopropoxyphenyl)acrylate (699).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476308B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-5af9a1c93e6846829084c5925533497b |
| Source note | uspto-grants-2013_07 |