Tazobactam → HCID 178429814, compound

HRID 445912Notes

Reaction equation

HRID 445912 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:13][C@@:14]1([CH2:27][N:28]2[N:32]=[N:31][CH:30]=[CH:29]2)[S:18](=[O:20])(=[O:19])[C@@H:17]2[CH2:21][C:22](=[O:23])[N:16]2[C@H:15]1[C:24]([OH:26])=[O:25]>O>[CH3:13][C@@:14]1([CH2:27][N:28]2[N:32]=[N:31][CH:30]=[CH:29]2)[S:18](=[O:19])(=[O:20])[C@@H:17]2[CH2:21][C:22](=[O:23])[N:16]2[C@H:15]1[C:24]([OH:26])=[O:25].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

4

Reactant 2

HCID 123630TazobactamHCID 178418600HCID 178418600, compound

Product 1

HCID 178429814HCID 178429814, compoundYield 101.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

L-arginine (2.9 g) was dissolved in 100 mL of deionized water and 5.0 g of tazobactam acid was then added, resulting a homogenous solution. The solution was lyophilized overnight to yield tazobactam arginine amorphous as an off-white solid (8.0 g). The XRPD spectrum of the tazobactam arginine amorphous is depicted in FIG. 5.

Workup

  1. customresulting a homogenous solution

Sources & evidence

ORD record
ord-2ed164214171428287188210e66bb688
Source dataset
uspto-grants-2013_07
Patent number
US08476425B1

Reaction notes

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