反应详情

To a solution of methyl 3,3-dimethyl-2,3-dihydrobenzofuran-6-carboxylate (0.116 g, 0.562 mmol) in MeOH (6 mL) at rt was added sodium hydroxide (1.969 mL, 1.969 mmol). The mixture was stirred at reflux for 1 h, and then concentrated under vacuum. The residue was diluted with water (20 mL) and extracted with ethyl acetate (2×40 mL). The combine extract was washed with brine (20 mL) and dried over anhydrous MgSO4. Removal of solvent under vacuum provided the desired product, 3,3-dimethyl-2,3-dihydrobenzofuran-6-carboxylic acid (0.105 g, 0.529 mmol, 94% yield), as a white solid.

1. temperatureat reflux for 1 h
2. concentrationconcentrated under vacuum
3. additionThe residue was diluted with water (20 mL)
4. extractionextracted with ethyl acetate (2×40 mL)
5. extractionThe combine extract
6. washwas washed with brine (20 mL)
7. dry with materialdried over anhydrous MgSO4
8. customRemoval of solvent under vacuum