反应详情

E-(7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide (3.0 g), ethyl alcohol (30.0 mL), and a solution of sodium hydroxide (0.4 g) in water (3.0 mL) were added to a reactor. The reaction mixture was stirred for 16 hours while maintaining the temperature of 20˜25° C. and then concentrated under reduced pressure. The resulting residue was dissolved in chloroform (10.0 mL) and then diethyl ether (100.0 mL) was added thereto. The reaction mixture was stirred for over 5 hours and then filtered under reduced pressure. The resulting white solid was dried under vacuum to obtain (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy hept-6-enoic acid sodium salt (2.4 g, yield 85%).

1. temperaturewhile maintaining the temperature of 20˜25° C.
2. concentrationconcentrated under reduced pressure
3. dissolutionThe resulting residue was dissolved in chloroform (10.0 mL)
4. additiondiethyl ether (100.0 mL) was added
5. stirringThe reaction mixture was stirred for over 5 hours
6. filtrationfiltered under reduced pressure
7. customThe resulting white solid was dried under vacuum