HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanethiol → HCID 86662502, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanethiol | HCID 15290 | — |
| Reactant | Dihydro-4-(2-methylpropyl)-2H-pyran-2,6(3H)-dione | HCID 11480690 | — |
| Product | HCID 86662502 | HCID 86662502 | — |
Reaction Steps
A schematic of the catalytic enantioselective thiolysis of 3-isobutylglutaric anhydride using cyclohexane thiol to afford (R)-3-cyclohexylsulfanylcarbonylmethyl-5-methyl-hexanoic acid is provided in FIG. 1. Thiolysis of 3-isobutylglutaric anhydride in methyltertbutylether (MTBE), at room temperature (rt) in the presence of catalytic quantities of C1 affords 3-cyclohexylsulfanylcarbonylmethyl-5-methyl-hexanoic acid in quantitative yield with the (R) enantiomer obtained in 93% ee.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476441B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-edf4098be17146188b6c8b89099af3cc |
| Source note | uspto-grants-2013_07 |