HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-(2-(dimethylamino)ethyl)-3-(6-formyl-3,4-dihydroquinolin-1(2H)-yl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 3-(3,4-dihydroquinolin-1(2H)-yl)-N-(2-(dimethylamino)ethyl) propanamide | HCID 59237977 | — |
| Product | N-(2-(dimethylamino)ethyl)-3-(6-formyl-3,4-dihydroquinolin-1(2H)-yl)propanamide | HCID 59237984 | — |
Reaction Steps
The procedure was carried out as described previously in step (a) of Example 5 with Compound 8 (0.74 g, 2.7 mmol), POCl3 (506 μL, 5.4 mmol), and DMF (8.6 mL). Compound 9 was obtained (0.31 g) as a viscous yellow liquid and used without any further purification. The structure of Compound 9 is given below:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476443B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-045131b07eae41c3be9135d49f24f348 |
| Source note | uspto-grants-2013_07 |