反应详情

温度

60 °C

To a solution of 1 g (2.4 mmol) of 8-[(1-benzylpiperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide in 90 mL of absolute ethanol 1 g of palladium on charcoal 10% w and 30 mL of 98% formic acid were added. The resulting mixture was stirred at 60° C. for 12 hours. The catalyst was then filtered on celite and the filtrate evaporated. The crude was purified by chromatography on a silica gel column eluted with a mixture CH2Cl2MeOH-Et3N, giving 350 mg (45% yield) of the title compound.

1. filtrationThe catalyst was then filtered on celite
2. customthe filtrate evaporated
3. customThe crude was purified by chromatography on a silica gel column
4. washeluted with a mixture CH2Cl2MeOH-Et3N