Piperidine → (Z)-ethyl-2-(5-oxo-2-thioxo-4-((5-(3-(tributylstannyl)phenyl)furan-2-yl)methylene)imidazolidin-1-yl)acetate

関与物質

反応条件

反応手順

5-(3-(Tributylstannyl)phenyl)furan-2-carbaldehyde (10 mg, 0.022 mmol) synthesized by the same method as in Example 4 and ethyl-2-(5-oxo-2-thioxoimidazolidin-1-yl)acetate (4.4 mg, 0.022 mmol) synthesized by the same method as in Example 2 were dissolved in dichloromethane (3 mL), piperidine (5 μL) was added thereto, and the mixture was stirred at room temperature (25° C.) overnight. After the reaction was completed the solvent was removed by evaporation under reduced pressure, and the residue was subjected to silica gel column chromatography using ethyl acetate/hexane (3/7 (volume ratio)) as an eluent, to give labeling precursor 2 in a yield of 11 mg (74.0%).

情報源と証拠