HCID 68861173, compound → HCID 57758710, compound

HRID 446098Notes

Reaction equation

HRID 446098 reaction equation
C(OC([N:11]1[CH2:15][CH:14]([O:16][CH3:17])[C:13]([NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])([CH3:18])[CH2:12]1)=O)C1C=CC=CC=1>CO.[H][H].[C].[Pd]>[C:23]([O:22][C:20]([NH:19][C:13]1([CH3:18])[CH:14]([O:16][CH3:17])[CH2:15][NH:11][CH2:12]1)=[O:21])([CH3:26])([CH3:25])[CH3:24]

Participants

5

Reactant 1

HCID 68861173HCID 68861173, compound

Product 1

HCID 57758710HCID 57758710, compound

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

To a solution of 1-benzyloxycarbonyl-3-(tert-butoxycarbonylamino)-4-methoxy-3-methylpyrrolidine (fraction β) (0.28 g, 0.77 mmol) in methanol (10 mL) was added 5% palladium-carbon (containing water, 0.14 g), and the mixture was stirred at room temperature for 18 hours in hydrogen atmosphere. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain the title compound as a colorless oily product. This product was used in the subsequent reaction without further purification. (ESI) m/z: 231 (M+H)+.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8d7435e846614fa9917d1850e19433fb
Source dataset
uspto-grants-2013_07
Patent number
US08476429B2

Reaction notes

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