HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 446131Generated: October 30, 2026
Thionyl Chloride → 1-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene
https://huagongshe.com/reaction/446131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-(Benzyloxy)-5-(tert-butyl)phenyl)methanol | HCID 59544156 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene | HCID 59544155 | — |
Reaction Steps
To a stirred solution of compound 4 (963 g, 3.56 mol) in anhydrous DCM (2000 mL) was added slowly SOCl2 (535 g, 4.5 mol) at 0° C. The mixture was stirred at 20° C. for 2 hours, then concentrated in vacuo to give compound 5 as an oil, which was used in the next reaction without further drying or purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476442B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-8940a1e941fb4171b0a959fe86624d68 |
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| Source note | uspto-grants-2013_07 |
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