1,3-Dichloroacetone → HCID 86612494, compound

HRID 446161Notes

Reaction equation

HRID 446161 reaction equation
[Cl:1][CH2:2][C:3](=[O:6])[CH2:4]Cl.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([SH:15])[CH:12]=[CH:13][CH:14]=1.[OH-].[Na+]>CO.O.O>[Cl:1][CH2:2][C:3](=[O:6])[CH2:4][S:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH3:7])[CH:10]=1

Participants

6

Reactant 3

HCID 107931,3-DichloroacetoneHCID 14798Sodium HydroxideHCID 849893-Methoxybenzenethiol

Product 1

HCID 86612494HCID 86612494, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
0 °C

Procedure

To a stirred solution of 1,3-dichloro-2-propanone (12.70 g, 0.1 mol) in methanol/water (100 ml, 1:3) at 0° C. is added a suspension of 3-methoxybenzenethiol (14.02 g, 0.1 mol) and sodium hydroxide (4.00 g, 0.10 g) in water (100 ml). The mixture is stirred at 0° C. for 7 h and at mom temperature for 10 h. The precipitated product is extracted with dichloromethane (100 ml), washed with water (80 ml), and dried with sodium sulfate. After removal of the solvent, we obtained the good product (oil, 18.70 g).

Workup

  1. extractionThe precipitated product is extracted with dichloromethane (100 ml)
  2. washwashed with water (80 ml)
  3. dry with materialdried with sodium sulfate
  4. customAfter removal of the solvent, we
  5. customobtained the good product (oil, 18.70 g)

Sources & evidence

ORD record
ord-9d6a0afa79214aecbd3430f550d03d82
Source dataset
uspto-grants-2013_07
Patent number
US08476455B2

Reaction notes

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