Aluminium lithium hydride → HCID 69442579, compound

Participants

Reaction Steps

To a solution of 6-benzyloxy-benzothiophene-2-carbaldehyde (described by Nomura Y., WO 9635688 A1, 6.50 g, 24.20 mmol) in THF (50 ml) was added dropwise to a −30° C. cooled suspension of LiAlH4 (0.85 g, 22.26 mmol). After warming up to room temperature the mixture was stirred overnight, cooled to −10° C., hydrolyzed with ice water, extracted with dichloromethane, dried over Na2SO4, filtered and concentrated under vacuum to give the crude product. Flash chromatography on silica gel (toluene/ethyl acetate: 7/3) yielded a limpid oil (4.50 g, 69%).

Provenance & Evidence