Potassium Fluoride → HCID 69444790, compound

Participants

Reaction Steps

Potassium fluoride (0.36 g, 6.14 mmol) in water (5 ml) was added to 4[N-[(2,2-dioxido-3-tosyl-3H-1,2,3-benzoxathiazol-5-yl)methyl]-N-(1H-imidazol-1-yl)amino]benzonitrile (1.60 g, 3.07 mmol) in acetonitrile (15 ml) at room temperature. The solution was stirred overnight, concentrated, extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under vacuum. Flash chromatography on silica gel (toluene/dioxane: 5/5) yielded an oil and crystallization from ethanol yielded the expected product (0.17 g, 15%, mp: 230° C.).

Provenance & Evidence