HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 44618Generated: October 29, 2026
Ammonium Hydroxide → 1-Methyl-8-(pyridin-2-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
https://huagongshe.com/reaction/44618
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | ethyl 1-methyl-8-(pyridin-2-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate | HCID 57444126 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Methyl-8-(pyridin-2-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | HCID 57444125 | — |
Reaction Steps
To a solution of ethyl 1-methyl-8-(pyridin-2-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (220 mg, 0.63 mmol) in methanol (250 mL), 33% aqueous ammonium hydroxide (100 mL) was added and the solution was stirred at 65° C. for 8 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08541429B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-9163dbbe249b4ef79c4da33f56e3e7d4 |
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| Source note | uspto-grants-2013_09 |
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