6-Bromonaphthalene-2-carbaldehyde → HCID 59270597, compound

Participants

Reaction Conditions

Reaction Steps

6-bromo-2-naphthaldehyde (4.0 g, 17.1 mmol) and diethyl-4-bromobenzylphosphonate (6.3 g, 20.5 mmol) were dissolved in purified dimethylsulfoxide (100 mL) under a nitrogen atmosphere, the reaction solution was cooled down to 0° C., and then potassium t-butoxide (2.5 g, 20.5 mmol) was slowly added thereto. The reaction mixture solution was stirred at room temperature for 12 hours. The reaction mixture solution was subjected to extraction with water and dichloromethane to thereby remove the solvent. The extracted material was sufficiently washed with methanol, and was dried in vacuum to thereby obtain a white solid (6.0 g, yield: 91%).

Provenance & Evidence