関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 2-Fluoro-5-methoxybenzoic acid | HCID 2774543 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Fluoro-5-hydroxybenzoic acid | HCID 2774480 | — |
反応手順
To 2-fluoro-5-methoxybenzoic acid (5.00 g, 29.4 mmol) was added 49% aqueous HBr (50 mL) and glacial acetic acid (40 mL). The mixture was heated overnight at 140° C., cooled to RT, diluted with ice water and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated to yield 2-fluoro-5-hydroxybenzoic acid. MS m/z=157 [M+1]+. Calc'd for C7H5FO3: 156.11.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08476434B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-fc4b6b7274f44b62a7cba79ca07bd297 |
|---|
| 出典メモ | uspto-grants-2013_07 |
|---|
