HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 16108985, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 16108985 | HCID 16108985 | — |
Reaction Steps
4-Chloro-6,7-dimethoxy-quinazoline (250 mg, 1.11 mmol), 2-fluoropyridine-3-boronic acid (173 mg, 1.22 mmol), Pd(PPh3)4 (128 mg, 0.11 mmol), DME (4.0 mL) and 1 M NaHCO3 (1.0 mL) were reacted in a manner similar to Example 72. MS m/z=286 [M+1]+. Calc'd for C15H12FN3O2: 285.28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476434B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-45ae0b7dcad2434aabc2983c7e5f5459 |
| Source note | uspto-grants-2013_07 |