3-(Trifluoromethyl)benzoyl chloride → HCID 58587741, compound

Participants

Reaction Steps

To 4-fluoro-N1-(3-(pyrimidin-4-yl)pyridin-2-yl)benzene-1,3-diamine (25 mg, 0.089 mmol) in CH2Cl2 (1.5 mL) was added 3-(trifluoromethyl)benzoyl chloride (21 mg, 0.098 mmol). The mixture was stirred overnight at RT. The crude material was purified by preparative TLC (100% EtOAc), which yielded the title compound as a yellow solid. MS m/z=454 [M+1]+. Calc'd for C23H15F4N5: 453.40.

Provenance & Evidence