反应详情

A suspension of ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (20.00 g, 66.368 mmol) in anhydrous ethanol (250 mL), 1.5M potassium hydroxide in ethanol (150 mL) was added under good stirring and the mixture was heated to reflux for 1.5 hours. After cooling in an ice bath, a solid was formed; that was filtered washing with ethanol, dried at 40° C. under vacuum to yield 17.34 g (yield 84%) of white solid compound.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 1.5 hours
4. temperatureAfter cooling in an ice bath
5. customa solid was formed
6. filtrationthat was filtered
7. washwashing with ethanol
8. customdried at 40° C. under vacuum