HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 44633Erstellt: 25. Oktober 2026
Iodine → 8-Iodo-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide
https://huagongshe.com/reaction/44633
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Iodine | HCID 807 | — |
| Edukt | Isoamyl Nitrite | HCID 8053 | — |
| Edukt | Cesium iodide | HCID 24601 | — |
| Edukt | Ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide | HCID 68936324 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | 8-Iodo-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide | HCID 44232945 | — |
Reaktionsschritte
In a round bottom flask maintained under argon atmosphere, ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide (13.00 g, 45.400 mmol) was dissolved into anhydrous dimethoxyethane (800 mL); cesium iodide (11.795 g, 45.400 mmol), bisublimated iodine (5.761 g, 22.698 mmol), copper(I) iodide (2.594 g, 13.621 mmol), and iso-amyl nitrite (9.107 mL, 68.100 mmol) were added in that order and the mixture was heated to 70° C. for 22 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08541429B2 |
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| Quelldatensatz | uspto-grants-2013_09 |
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| ORD ID | ord-1712e10069594564bdddcc990bb7193f |
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| Quellennotiz | uspto-grants-2013_09 |
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