反应详情

温度

100 °C

To N-(4-amino-2-fluorophenyl)-2,3-dichlorobenzenesulfonamide (0.150 g, 0.45 mmol) and 4-(2-chloropyridin-3-yl)pyrimidine (0.086 g, 0.45 mmol) was added NEt3.TFA. The mixture was heated at 100° C. CH2Cl2/MeOH was added, producing a yellow precipitate, which was filtered. Trituration with a further portion of CH2Cl2/MeOH, followed by filtration, afforded 2,3-dichloro-N-(2-fluoro-4-(3-(pyrimidin-4-yl)pyridin-2-ylamino)phenyl)benzenesulfonamide as an orange solid. MS m/z=491 [M+H]+. Calc'd for C21H14Cl2FN5O2S: 490.35.

1. customproducing a yellow precipitate, which
2. filtrationwas filtered
3. filtrationTrituration with a further portion of CH2Cl2/MeOH, followed by filtration