HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1S)-2-morpholin-4-yl-1-phenylethanamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl (1S)-2-morpholin-4-yl-1-phenylethylcarbamate | HCID 57444157 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1S)-2-morpholin-4-yl-1-phenylethanamine dihydrochloride | HCID 57463845 | 90% |
Reaction Steps
A solution of 11.58 g (0.0378 mol) of tert-butyl (1S)-2-morpholin-4-yl-1-phenylethylcarbamate in 100 mL of dichloromethane was treated with 120 mL of HCl 4M in dioxane and stirred for 18 hours. The mixture was diluted with diethylether and the product filtered (9.48 g, 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541429B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-844ed63e57b24cd986691df297edc7cf |
| Source note | uspto-grants-2013_09 |