HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-(Hydroxymethyl)phenyl)prop-2-yn-1-ol → 3-(3-(Hydroxymethyl)phenyl)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-(Hydroxymethyl)phenyl)prop-2-yn-1-ol | HCID 58168552 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(3-(Hydroxymethyl)phenyl)propan-1-ol | HCID 55267680 | — |
Reaction Steps
A solution of 3-(3-(hydroxymethyl)phenyl)prop-2-yn-1-ol [Aromatic Intermediate 18, step a] (0.44 g) in ethanol (20 mL) was hydrogenated using an H-Cube™ Hydrogenation Reactor (ThalesNano Nanotechnology Inc) with 10% Pd/C catalyst at 50° C. and 40 bar. The solution was passed through the H-cube three times, and concentrated in vacuo to afford the subtitled compound as a pale yellow oil. Yield (0.40 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476265B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-20aee5317a1b4047a315fce41189195e |
| Source note | uspto-grants-2013_07 |