反应详情

Manganese dioxide (2.07 g) was added to a solution of 3-(3-(hydroxymethyl)phenyl)propan-1-ol [Aromatic Intermediate 18, step b] (0.40 g) in dichloromethane (20 mL) and the mixture stirred at ambient temperature for 18 hours. The mixture was filtered through Celite and concentrated in vacuo. The crude product was purified by flash silica chromatography, elution gradient 40%, 50% and 60% ethyl acetate in isohexane. Fractions containing the product were evaporated to dryness to afford the titled compound as a colourless oil. Yield 0.21 g.

1. filtrationThe mixture was filtered through Celite
2. concentrationconcentrated in vacuo
3. customThe crude product was purified by flash silica chromatography, elution gradient 40%, 50% and 60% ethyl acetate in isohexane
4. additionFractions containing the product
5. customwere evaporated to dryness