反应详情

温度

0 °C

Sodium borohydride (1.40 g) was added portionwise to a stirred solution at 0° C. of 4-(2-(tert-butyldimethylsilyloxy)ethyl)thiophene-2-carbaldehyde [Aromatic Intermediate 6] (10 g) in ethanol (70 mL). The reaction mixture was stirred for 1 hour at 0° C. and then partitioned between ethyl acetate and aqueous brine and separated. The organic layer was dried, filtered and the solvent was evaporated under reduced pressure. The crude product was purified by flash silica chromatography using 12% ethyl acetate in isohexane as solvent. Fractions containing the product were evaporated to dryness to afford the subtitled compound. Yield 6.00 g.

1. custompartitioned between ethyl acetate and aqueous brine
2. customseparated
3. customThe organic layer was dried
4. filtrationfiltered
5. customthe solvent was evaporated under reduced pressure
6. customThe crude product was purified by flash silica chromatography
7. additionFractions containing the product
8. customwere evaporated to dryness