Tetrabutylammonium Fluoride → HCID 58168497, compound

Participants

Reaction Steps

TBAF (1M in THF, 3.65 mL) was added dropwise to a solution of 2-(4-(2-(tert-butyldimethylsilyloxy)ethyl)thiophen-2-yl)ethyl acetate [Aromatic Intermediate 21, step a] (1.2 g) in dry THF (30 mL). This solution was allowed to stand at 20° C. for 1 hour, then the solvents were evaporated under reduced pressure and the residue was purified by flash silica chromatography, using 40% ethyl acetate in isohexane as solvent. Fractions containing the product were evaporated to dryness to afford the subtitled compound. Yield 0.63 g.

Provenance & Evidence