HRID446444

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3024915

N-(2,2-dimethoxyethyl)cyclohexanamine

C10H21NO2

结构：CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(CCOCCC(=O)O)c4Cl)CC3)C2)cs1

HCID58168459

未命名化合物

PRODUCTS

生成物

结构：COC(CN(C(=O)CCOCCc1cccc(CN2CCC3(CC2)CN(C(=O)c2csc(C(C)C)n2)CCO3)c1Cl)C1CCCCC1)OC

HCID58168528

未命名化合物

PROCEDURE

实验过程

Prepared by the method of Example 7, step e using 3-(2-chloro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid [Example 27, step d] (0.28 g) in place of 3-(2-fluoro-3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenethoxy)propanoic acid, and N-(2,2-dimethoxyethyl)cyclohexanamine [WO 2008075025] (0.10 g) in place of N-(2,2-dimethoxyethyl)cycloheptanamine. Yield 0.11 g.

WORKUP

后处理

customPrepared by the method of Example 7, step e

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-47f19e4eded64a1e8170029dcb4f141a
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476265B2
来源说明: uspto-grants-2013_07

反应 SMILES

[Cl:1][C:2]1[C:15]([CH2:16][N:17]2[CH2:37][CH2:36][C:20]3([O:25][CH2:24][CH2:23][N:22]([C:26]([C:28]4[N:29]=[C:30]([CH:33]([CH3:35])[CH3:34])[S:31][CH:32]=4)=[O:27])[CH2:21]3)[CH2:19][CH2:18]2)=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9](O)=[O:10].[CH3:38][O:39][CH:40]([O:49][CH3:50])[CH2:41][NH:42][CH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1>>[Cl:1][C:2]1[C:15]([CH2:16][N:17]2[CH2:18][CH2:19][C:20]3([O:25][CH2:24][CH2:23][N:22]([C:26]([C:28]4[N:29]=[C:30]([CH:33]([CH3:34])[CH3:35])[S:31][CH:32]=4)=[O:27])[CH2:21]3)[CH2:36][CH2:37]2)=[CH:14][CH:13]=[CH:12][C:3]=1[CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9]([N:42]([CH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1)[CH2:41][CH:40]([O:49][CH3:50])[O:39][CH3:38])=[O:10]