反应详情

Triton-B (0.3 molar equivalents of a 40% solution in water) was added to a solution of (9-(2-chloro-3-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-ethylthiazol-4-yl)methanone (limiting reagent) (step c) and tert-butyl acrylate (5 molar equivalents) in acetonitrile (3.4 volumes). The reaction was stirred at ambient temperature for 1 hr. The solvent was evaporated and the residue was partitioned between water (2 volumes) and 2-MeTHF (2 volumes). The layers were separated and the organics were dried over anhydrous sodium sulfate, filtered and evaporated to give a brown oil. Yield: 94% of theoretical.

1. customThe solvent was evaporated
2. customthe residue was partitioned between water (2 volumes) and 2-MeTHF (2 volumes)
3. customThe layers were separated
4. dry with materialthe organics were dried over anhydrous sodium sulfate
5. filtrationfiltered
6. customevaporated
7. customto give a brown oil