HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 446457Generated: October 27, 2026
Hydrochloric Acid → (2-Isopropylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone hydrochloride
https://huagongshe.com/reaction/446457
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate | HCID 57989200 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | (2-Isopropylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone hydrochloride | HCID 66964119 | 97% |
Reaction Steps
To a solution of tert-butyl 4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate in iPrOH (3 volumes) at 40° C. under nitrogen was added a solution of 5-6N HCl in isopropanol (2-2.4 molar equivalents). The mixture was stirred at 40° C. for 18 hours, cooled to room temp and diluted with TBME (4 volumes). Stirred at room temp for 2 hours, collected by filtration, washed with TBME and air dried to leave an off white powder. Yield: 97% of theoretical.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08476265B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-8347daa88b0140969db5375dce31758d |
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| Source note | uspto-grants-2013_07 |
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