反应详情

温度

20 °C

A solution of sodium carbonate (1.4 g) in water (40 mL) was added to a solution of 2,2,2-trifluoro-1-(9-(2-fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone [Example 44, step b] (4.2 g) in acetonitrile (40 mL). The reaction mixture was stirred at 20° C. for 20 hours. The acetonitrile was removed under reduced pressure and the remaining aqueous solution was extracted with DCM (×9). The combined DCM extracts were dried, filtered and the solvent removed under reduced pressure to yield the subtitled compound. Yield 2.7 g.

1. customThe acetonitrile was removed under reduced pressure
2. extractionthe remaining aqueous solution was extracted with DCM (×9)
3. dry with materialThe combined DCM extracts were dried
4. filtrationfiltered
5. customthe solvent removed under reduced pressure