Acetic Acid → HCID 86663414, compound

Participants

Reaction Steps

A solution of tetrabutylammonium fluoride in tetrahydrofuran (1.0 M, 508 mL) and acetic acid (70 mL, 1.27 mol) were added to a solution of the compound (131.76 g, 0.254 mol) obtained in Example 1b in tetrahydrofuran (500 mL), and the mixture was stirred at room temperature for 2 hours. Ethyl acetate (1000 mL) was added to the reaction mixture, washed with a saturated aqueous solution of sodium hydrogencarbonate, water, and saturated sodium chloride solution, dried with anhydrous sodium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate-n-hexane, 30%→50%) to give the title compound (102.11 g; yield, 99%) as a colorless oily substance.

Provenance & Evidence