反应详情

A solution of the compound (300 mg, 0.810 mmol) obtained in Example 12a in methanol (8 mL) was added to 10% palladium-carbon (dry; 30 mg), the atmosphere in the system was replaced with a hydrogen atmosphere, and then the mixture was stirred at room temperature for 30 minutes. The atmosphere in the system was replaced with a nitrogen atmosphere, then 10% palladium-carbon (dry; 90 mg) was further added, the atmosphere in the system was replaced with a hydrogen atmosphere, and the mixture was stirred at room temperature for 30 minutes. The atmosphere in the system was replaced with a nitrogen atmosphere, and then the mixture was filtered through celite. The solvent was evaporated under reduced pressure to give the title compound (260 mg; yield, 95%) as a light brown oily substance.

1. stirringthe mixture was stirred at room temperature for 30 minutes
2. filtrationthe mixture was filtered through celite
3. customThe solvent was evaporated under reduced pressure