Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → HCID 86761902, compound

HRID 446524Notes

Reaction equation

[C:1]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:28])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([CH3:27])[C:19](=[O:26])[CH2:20][O:21][CH2:22][CH2:23][CH:24]=O)[CH2:12][CH2:11]1.[NH2:35][C:36]1[CH:48]=[CH:47][C:39]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])=[CH:38][CH:37]=1>>[C:1]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([CH3:27])[C:19](=[O:26])[CH2:20][O:21][CH2:22][CH2:23][CH2:24][NH:35][C:36]2[CH:48]=[CH:47][C:39]([C:40]([O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:41])=[CH:38][CH:37]=2)[CH2:12][CH2:11]1)=[O:28]

Participants

Reactant 2

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl ester

HCID 86761903HCID 86761903, compound

Product 1

HCID 86761902HCID 86761902, compoundYield 63%

Procedure

The compound (222 mg, 0.475 mmol) obtained in Example 26c and tert-butyl 4-aminobenzoate (92 mg, 0.475 mmol) were used according to the method described in Example 18b to give the title compound (192 mg; yield, 63%) as a white solid.

Sources & evidence

ORD record: ord-cc889f5599684a8590e9faa78bfce7e2
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08476253B2

Reaction notes

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