Trifluoroacetic acid → HCID 86663439, compound

Participants

Reaction Steps

The compound (129 mg, 0.292 mmol) obtained in Example 30c was dissolved in methylene chloride (3 mL), trifluoroacetic acid (1.5 mL) was added under ice cooling, and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, toluene (×2) was added to the resulting residue, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in methylene chloride (3 mL), triethylamine (0.318 mL, 2.29 mmol) and di-tert-butyl dicarbonate (244 mg, 1.75 mmol) were added, and the mixture was stirred at room temperature for 15 hours. The solvent was evaporated under reduced pressure, and the resulting residue was purified by NH silica gel column chromatography (hexane:ethyl acetate=1:2→0:100, v/v) to give the title compound (78 mg; yield, 78%) as a yellow oily substance.

Provenance & Evidence