Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → HCID 86761904, compound

HRID 446531Notes

Reaction equation

[C:1]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:26])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([CH3:25])[C:19](=[O:24])[CH2:20][CH2:21][CH:22]=O)[CH2:12][CH2:11]1.[NH2:33][C:34]1[CH:46]=[CH:45][C:37]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])=[CH:36][CH:35]=1>>[C:1]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([CH3:25])[C:19](=[O:24])[CH2:20][CH2:21][CH2:22][NH:33][C:34]2[CH:46]=[CH:45][C:37]([C:38]([O:40][C:41]([CH3:42])([CH3:43])[CH3:44])=[O:39])=[CH:36][CH:35]=2)[CH2:12][CH2:11]1)=[O:26]

Participants

Reactant 2

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl ester

HCID 86761905HCID 86761905, compound

Product 1

HCID 86761904HCID 86761904, compoundYield 83%

Procedure

The compound (130 mg, 0.297 mmol) obtained in Example 33b and tert-butyl 4-aminobenzoate (92 mg, 0.475 mmol) were used to give the title compound (151 mg; yield, 83%) as a white solid according to the method described in Example 18b.

Sources & evidence

ORD record: ord-5c82426bd3c04b38aa802430c4992c09
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08476253B2

Reaction notes

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