HRID446536

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22291264

tert-Butyl 4-(methylamino)benzoate

C12H17NO2

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCCO

HCID66671691

未命名化合物

PRODUCTS

生成物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCCN(C)c1ccc(C(=O)OC(C)(C)C)cc1

HCID66793798

未命名化合物

收率 26%

PROCEDURE

实验过程

The compound (163 mg, 0.338 mmol) obtained in Example 39b was used according to the method described in Example 4g to give a crude aldehyde compound (160 mg). The resulting crude aldehyde compound and the compound (69 mg, 0.334 mmol) obtained in Example 35a were used a to give the title compound (58 mg; yield, 26%) as a white solid according to the method described in Example 18b.

WORKUP

后处理

customto give a crude aldehyde compound (160 mg)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b9877a9894fa46bf9c25d28370f9c3f3
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[C:1]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:29])[O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][N:18]([C:20](=[O:28])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]O)[CH3:19])[CH2:12][CH2:11]1.[CH3:36][NH:37][C:38]1[CH:50]=[CH:49][C:41]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])=[CH:40][CH:39]=1>>[C:45]([O:44][C:42](=[O:43])[C:41]1[CH:49]=[CH:50][C:38]([N:37]([CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][C:20]([N:18]([CH2:17][CH2:16][N:13]2[CH2:14][CH2:15][CH:10]([O:9][C:8](=[O:29])[NH:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:11][CH2:12]2)[CH3:19])=[O:28])[CH3:36])=[CH:39][CH:40]=1)([CH3:47])([CH3:46])[CH3:48]