HRID446544

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66671362

未命名化合物

结构：CNCCCN(C)C(=O)CO[C@H]1Cc2ccccc2C12CCN(CC[C@@]1(c3ccc(F)cc3)CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CO1)CC2

HCID86663419

未命名化合物

PRODUCTS

生成物

结构：CN(CCCN(C)C(=O)c1ccc(CCN(C)C(=O)OC(C)(C)C)cc1)C(=O)CO[C@H]1Cc2ccccc2C12CCN(CC[C@@]1(c3ccc(F)cc3)CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CO1)CC2

HCID86663448

未命名化合物

收率 92%

PROCEDURE

实验过程

The compound (140 mg, 0.501 mmol) obtained in Example 50a and the compound (260 mg, 334 mol) obtained in Example 1k were used to give the title compound (320 mg; yield, 92%) as a white solid according to the method described in Example 41a.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bbcea42410404bcd815290b0d54aadce
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[C:1]([O:5][C:6]([N:8]([CH3:20])[CH2:9][CH2:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:21][C:22]([F:75])([F:74])[C:23]1[CH:24]=[C:25]([CH:67]=[C:68]([C:70]([F:73])([F:72])[F:71])[CH:69]=1)[C:26]([N:28]1[CH2:32][C@@:31]([CH2:40][CH2:41][N:42]2[CH2:47][CH2:46][C:45]3([C:55]4[C:50](=[CH:51][CH:52]=[CH:53][CH:54]=4)[CH2:49][C@@H:48]3[O:56][CH2:57][C:58]([N:60]([CH3:66])[CH2:61][CH2:62][CH2:63][NH:64][CH3:65])=[O:59])[CH2:44][CH2:43]2)([C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)[O:30][CH2:29]1)=[O:27]>>[F:73][C:70]([F:71])([F:72])[C:68]1[CH:67]=[C:25]([CH:24]=[C:23]([C:22]([F:21])([F:75])[F:74])[CH:69]=1)[C:26]([N:28]1[CH2:32][C@@:31]([CH2:40][CH2:41][N:42]2[CH2:43][CH2:44][C:45]3([C:55]4[C:50](=[CH:51][CH:52]=[CH:53][CH:54]=4)[CH2:49][C@@H:48]3[O:56][CH2:57][C:58]([N:60]([CH3:66])[CH2:61][CH2:62][CH2:63][N:64]([CH3:65])[C:15]([C:14]3[CH:13]=[CH:12][C:11]([CH2:10][CH2:9][N:8]([CH3:20])[C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:19][CH:18]=3)=[O:17])=[O:59])[CH2:46][CH2:47]2)([C:33]2[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=2)[O:30][CH2:29]1)=[O:27]