HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Formyl-2-thiophenecarboxylic Acid → tert-Butyl (3-{[(5-formyl-2-thienyl)carbonyl](methyl)amino}propyl)methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Formyl-2-thiophenecarboxylic Acid | HCID 818882 | — |
| Reactant | tert-butyl N-methyl-N-(3-(methylamino)propyl)carbamate | HCID 17868293 | — |
| Product | tert-Butyl (3-{[(5-formyl-2-thienyl)carbonyl](methyl)amino}propyl)methylcarbamate | HCID 86663450 | 83% |
Reaction Steps
5-Formylthiophene-2-carboxylic acid (300 mg, 1.92 mmol) and tert-butyl methyl[3-(methylamino)propyl]carbamate (466 mg, 2.31 mmol) were used to give the title compound (517 mg; yield, 83%) as a colorless oily substance according to the method described in Example 41a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476253B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-fa8db9b52ca240499b6400f1f58a068e |
| Source note | uspto-grants-2013_07 |