HRID446550

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(CCCN(C)C(=O)Cc1ccc(N)cc1)C(=O)CO[C@H]1Cc2ccccc2C12CCN(CC[C@@]1(c3ccc(F)cc3)CN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CO1)CC2

HCID86663452

未命名化合物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCC=O

HCID86761901

未命名化合物

PRODUCTS

生成物

结构：CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)CCCCCNc1ccc(CC(=O)N(C)CCCN(C)C(=O)CO[C@H]2Cc3ccccc3C23CCN(CC[C@@]2(c4ccc(F)cc4)CN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CO2)CC3)cc1

HCID86761909

未命名化合物

收率 32%

PROCEDURE

实验过程

The compound (194 mg, 0.219 mmol) obtained in Example 57b and the compound (102 mg, 0.219 mmol) obtained in Example 4g were used to give the title compound (95 mg; yield, 32%) as a white solid according to the method described in Example 41b.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5308faacdfa84e06bf3fe0d8ab10447b
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476253B2
来源说明: uspto-grants-2013_07

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:11]([CH2:13][CH2:14][CH2:15][N:16]([C:18](=[O:65])[CH2:19][O:20][C@@H:21]2[C:29]3([CH2:34][CH2:33][N:32]([CH2:35][CH2:36][C@:37]4([C:58]5[CH:63]=[CH:62][C:61]([F:64])=[CH:60][CH:59]=5)[O:41][CH2:40][N:39]([C:42](=[O:57])[C:43]5[CH:48]=[C:47]([C:49]([F:52])([F:51])[F:50])[CH:46]=[C:45]([C:53]([F:56])([F:55])[F:54])[CH:44]=5)[CH2:38]4)[CH2:31][CH2:30]3)[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22]2)[CH3:17])[CH3:12])=[O:10])=[CH:4][CH:3]=1.[C:66]1([C:94]2[CH:99]=[CH:98][CH:97]=[CH:96][CH:95]=2)[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=1[NH:72][C:73](=[O:93])[O:74][CH:75]1[CH2:80][CH2:79][N:78]([CH2:81][CH2:82][N:83]([CH3:92])[C:84](=[O:91])[CH2:85][CH2:86][CH2:87][CH2:88][CH:89]=O)[CH2:77][CH2:76]1>>[C:66]1([C:94]2[CH:95]=[CH:96][CH:97]=[CH:98][CH:99]=2)[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=1[NH:72][C:73](=[O:93])[O:74][CH:75]1[CH2:80][CH2:79][N:78]([CH2:81][CH2:82][N:83]([C:84](=[O:91])[CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:11]([CH2:13][CH2:14][CH2:15][N:16]([C:18](=[O:65])[CH2:19][O:20][C@@H:21]3[C:29]4([CH2:30][CH2:31][N:32]([CH2:35][CH2:36][C@:37]5([C:58]6[CH:63]=[CH:62][C:61]([F:64])=[CH:60][CH:59]=6)[O:41][CH2:40][N:39]([C:42](=[O:57])[C:43]6[CH:44]=[C:45]([C:53]([F:54])([F:56])[F:55])[CH:46]=[C:47]([C:49]([F:50])([F:51])[F:52])[CH:48]=6)[CH2:38]5)[CH2:33][CH2:34]4)[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22]3)[CH3:17])[CH3:12])=[O:10])=[CH:4][CH:3]=2)[CH3:92])[CH2:77][CH2:76]1